NR4A nuclear receptor regulation and activity during organ formation
Our laboratory studies the NR4A group of orphan nuclear receptors. This functionally
diverse group of transcription factors has context-dependent roles in regulations
cell proliferation, differentiation, quiescence, and survival. They are emerging as
important factors in the tiology of several diseases including atherosclerosis, cancer,
and neurodegeneration. Our focus is on understanding the cellular mechanisms of NR4A
NR function with an emphasis in deciphering downstream transcriptional outputs and
the modulation of NR4A NR activity at the protein level.
We study this transcription factor using the Caenorhabdities elegans genetic model systgem. We have determined that the NR4A NR homolog in C. elegans, NHR-6, regulates cell proliferation and cell differentiation during development of a somatic gonad organ, the spermatheca. This structurally simple, yet functionally complex organ system provides an ideal system for investigating the regulation of distinct NR4A NR activities. Our current research program is focused on the following:
The goal of our research is to discover NR4A signaling pathways that can provide new insight into the role of NR4A in disease models.
Developmental functions of extracellular leucine-rich repeat proteins (eLRRs)
We are also interested in the developmental functions of eLRR proteins in C. elegans. eLRRs are a diverse superfamily of proteins with important functions in innate immunity and nervous system development. We are interested in defining roles for these proteins in cellular differentiation and tissue morphogenesis. This particular biological functions of eLRRs have yet to be extensively characterized.
|Chris R. Gissendanner, Ph.D.
Department of Basic Pharmaceutical Sciences
School of Pharmacy
University of Louisiana at Monroe
Monroe, LA 71209-0497