Currently our laboratory is characterizing the intracellular mechanisms mediating
the antiproliferative and cytotoxic effects of tocotrienols in isolated normal, preneoplastic
and neoplastic mouse mammary epithelial cells. Tocotrienols and tocopherols represent
the two subgroups of compounds that make up the Vitamin E family. However, experimental
evidence indicates that tocotrienols have significantly greater anticancer activity
than tocopherols, suggesting that tocotrienols may have significant value as therapeutic
agents for breast cancer prevention and/or treatment.
The chemoprotective effects of tocotrienols are of particular interest because these compounds attenuate growth factor-induced mitogenesis and induce apoptosis at significantly lower doses in tumor versus normal mammary epithelial cells. Characterization of the intracellular mechanism(s) of action of tocotrienols would provide essential information necessary for understanding the potential health benefits of these compounds in preventing and/or reducing the risk of breast cancer in women.
|Paul W. Sylvester, Ph.D.
B. J. Robison/Pfizer Endowed Professor
Professor of Pharmacology
Department of Basic Pharmaceutical Sciences
School of Pharmacy
University of Louisiana at Monroe
Monroe, LA 71209-0497