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School of Pharmacy
Basic Pharmaceutical Sciences

Publications of Dr. Paul Sylvester

164. Algayadh, I.G. and Sylvester, P.W.  (2017)  Synergistic Anticancer Effects of Combined g-Tocotrienoland Pterostilbene Is Associated With a Suppression in Rac1/WAVE 2 Signaling in Highly Malignant Breast Cancer Cells.  (submitted)
163. Alawin, O.A., Ahmed, R.A., Dronamraju, V., Briski, K.P. and Sylvester, P.W.  (2017)  γ-Tocotrienol-Induced Disruption of Lipid Rafts in Human Breast Cancer Cells is Associated with a Reduction in Exosome Heregulin Content.  Journal of Nutrition and Biochemistry.  (submitted)
162. Briski, K.P., Alenazi, F., Shakya, M. and Sylvester, P.W.  (2017)  Hindbrain A2 Noradrenergic Neuron Adenosine 5’-Monophosphate-Activated Protein Kinase (AMPK) Activation, Upstream Kinase/Phosphorylase Protein Expression, and Receptivity to Hormone and Fuel Reporters of Short-Term Food Deprivation are Regulated by Estradiol.  Journal of Neuroscience (in press)
161. Sylvester, P.W. and Tiwari, R.V.  (2016)  Role of Autophagy in Mediating the Anticancer Effects of Tocotrienols.  In: Autophagy in Current Trends in Cellular Physiology and Pathology, Eds. Andrea Koric, InTech Publications.  http://dx.doi.org/10.5772/64131
160. Alawin, O., Ahmed, R.A., Dronamraju, V., Algayadh, I.G., Kalloub, A.A. and Sylvester, P.W. (2016)  Role of Endoplasmic Retiulum Stress in Mediating the Anticancer Effects of Tocotrienols.  In: Endoplasmic Reticulum Stress: Regulation, Function and Role in Health and Disease, pp 101-128. Eds, Cameron Wagner, Nova Science Publisher, Inc. Hauppauge, NY
159. Algayadh, E.G., Dronamraju V. and Sylvester, P.W.  (2016)  g-Tocotrienol Inhibition of Cell Migration and Invasion Is Associated With a Suppression in WAVE 2 Signaling in Highly Malignant Breast Cancer Cells.  Biological and Pharmaceutical Bulletin 39(12):1974-1982
158. Ahmed, A.R., Alawin, O.A. and Sylvester, P.W.  (2016)  γ-Tocotrienol reversal of Epithelial-to-Mesenchymal Transition in Human Breast Cancer Cells is Associated with an Inhibition in Canonical Wnt Signaling.  Cell Proliferation 49:460-470
157. Klionsky, D.J., Abdelmoshsen, K., Abe, A., et al.  (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3nd edition).  Autophagy 12:1-222
156. Alawin, O.A., Ahmed, R.A., Ibrahim, B.A., Briski, K.P. and Sylvester, P.W.  (2016)  Antiproliferative effects of γ-tocotrienol are associated with lipid raft disruption in HER2 positive breast cancer cells.  Journal of Nutritional Biochemistry 27:266-277
155. Abu Fayyad, A.; Behery, F. Sallam, A., Alqahtani, S., Ebrahim, H., El Sayed, K. Kaddoumi, A., Sylvester, P.W., Carroll, J., Cardelli, J. and Nazzal, S.  (2015)  PEGylated γ-tocotrienol isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability.  European Journal of Pharmaceutics and Biopharmaceutics 96:185-195
154. Tiwari, R.V., Parajuli, P. and Sylvester, P.W.  (2015)  Synergistic Anticancer Effects of Combined γ-Tocotrienol and Oridonin Treatment is Associated with the Induction of Autophagy.  (2015)  Molecular and Cellular Biochemistry 93:306-320. doi: 10.1139/bcb-2014-0123
153. Parajuli, P., Tiwari, R.V. and Sylvester P.W.  (2015)  Anticancer Effects of g-Tocotrienol are Associated with a Suppression in Aerobic Glycolysis.  Biological and Pharmaceutical Bulletin. 38: 1352-1360. doi: 10.1248/bpb.b15-00306
152. Parajuli, P., Tiwari, R.V., and Sylvester, P.W.  (2015)  Antiproliferative Effects of g-Tocotrienol are Associated with a Suppression in c-Myc Expression in Mammary Tumor Cells”.  Cell Proliferation. 48:421-432
151. Tiwari, R.V., Parajuli, P., and Sylvester, P.W.  (2015)  g-Tocotrienol-Induced Autophagy Promotes Endoplasmic Reticulum Stress Mediated Apoptosis in Breast Cancer.  Biochemistry and Cell Biology. 93:306-320. doi: 10.1139/bcb-2014-0123
150. Alqahtani, S., Simon, L., Astete, C., Alayoubi, A., Sylvester, P.W., Nazzal, S., Shen, Y., Xu, Z., Kaddoumi, A., and Sabliov, C.M.  (2015)  Cellular uptake, antioxidant and antiproliferative activity of entrapped α-tocopherol and γ-tocotrienol in poly (lactic-co-glycolic) acid (PLGA) and chitosan covered PLGA nanoparticles (PLGA-Chi) Journal of Colloid and Interface Science 445:243-251.  doi:10.1016/j.jcis.2014.12.083
149. Sylvester, P.W.  (2014)  Combined g-Tocotrienol and Met Inhibitor Treatment Suppresses Mammary Cancer Cell Proliferation, Epithelial-to-Mesenchymal Transition, and Migration.  Journal of Oil Palm, Environment & Health 2014, 5:18-30.  doi:10.5366/jope.2014.03
148. Sylvester, P.W.  (2014)  Targeting Met mediated epithelial-mesenchymal transition in the treatment of cancer.  Clinical and Translational Medicine 3:30.  http://www.clintransmed.com/content/3/1/30, doi:10.1186/s40169-014-0030-5
147. Ananthula, S., Parajuli, P., Behery, F.A., El Sayed, K.A., and Sylvester, P.W.  (2014)  δ-Tocotrienol Oxazine Derivative Antagonizes Mammary Tumor Cell Compensatory Responses to CoCl2-Induced Hypoxia.  Biomed Res International 2014:285752.  doi: 10.1155/2014/285752
146. Alayoubi, A., Abu-Fayyad, A., Rawas-Qalaji, M.M., Sylvester, P.W. and Nazzal, S.  (2015)  Effect of lipid viscosity and high-pressure homogenization on the physical stability of “Vitamin E” enriched emulsion. Pharmaceutical Development and Technology 20:555-561.  doi: 10.3109/10837450.2014.898655
145. Alqahtani, S. Alayoubi, A., Nazzal, S., Sylvester, P.W. and Kaddoumi, A.  (2014)  Enhanced solubility and oral bioavailability of g-tocotrienol using a self-emulsifying drug delivery system (SEDDS).  Lipids 49:819-829
144. Ananthula, S., Parajuli, P., Behery, F.A., Alayoubi, A.Y., El Sayed, K.A., Nazzal, S. and Sylvester, P.W.  (2014)  Oxazine Derivatives of γ- and δ- Tocotrienol Display Enhanced Anticancer Activity In VivoAnticancer Research 34:2715-2726
143. Alayoubi, A., Ayoub, N.M., Malaviya, A., Sylvester, P.W., and Nazzal, S.  (2014)  Entrapment Into Nanoemulsions Potentiates the Anticancer Activity of Tocotrienols Against the Highly Malignant (+SA) Mouse Mammary Epithelial Cells.  Journal of Nanoscience and Nanotechnology 14:4002-4005
142. Malaviya, A., and Sylvester P.W.  (2014)  Antiproliferative Effects of combined treatment of γ–Tocotrienol with PPARγ Agonists or Antagonists mediated through PPARγ-independent mechanisms in breast cancer cells.  PPAR Research http://dx.doi.org/10.1155/2014/439146
141. Sylvester, P.W., Ananthula, S., Parajuli, P., Akl, M.R., Malaviya, A., Tiwari, R.V., Alawin, O., and Ayoub, N.M.  (2014)  Potential role of tocotrienols in the treatment and prevention of breast cancer.  Biofactors 40(1):49-58. doi: 10.1002/biof.1116
140. Malaviya, A., Parajuli, P. and Sylvester, P.W.  (2014)  Synergistic Antiproliferative Effects of Combined PPARγ Antagonist and γ-Tocotrienol Treatment Suppress Adipogenic Factors in Breast Cancer Cells.  JPANS 4:43-56.  DOI: http://dx.doi.org/10.6000/1927-5951.2014.04.01.7
139. Tiwari, R.V., Parajuli, P., and Sylvester, P.W.  (2014)  g-Tocotrienol-Induced Autophagy in Malignant Mammary Cancer Cells.  Experimental Biology and Medicine 239:33-44
138. Ayoub, N.M., Akl, M.R. and Sylvester, P.W.  (2013)  Combined g-Tocotrienol and Met Inhibitor Treatment Suppresses Cancer Cell Proliferation, Epithelial-to-Mesenchymal Transition, and Migration.  Cell Proliferation 46:538-553
137. Sylvester, P.W. and Ayoub, N.M.  (2013)  Tocotrienols Target PI3K/Akt Signaling in Anti-Breast Cancer Therapy.  Anti-Cancer Agents in Medicinal Chemistry 13:1039-1047
136. Alqahtani, S., Alayoubi, A., Nazzal, S., Sylvester, P.W. and Kaddoumi, A.  (2013)  Non-Linear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: In Vivo and In Vitro Studies.  American Association of Pharmaceutics Journal doi: 10.1208/s12248-013-9481-7
135. Malaviya, A. and Sylvester, P.W.  (2013)  Mechanisms mediating the effects of γ–tocotrienol used in combination with PPARγ agonists or antagonists on MCF-7 and MDA-MB-231 breast cancer cell proliferation.  International Journal of Breast Cancer http://dx.doi.org/10.1155/2013/101705
134. Alayoubi, A., Nazzal, M., Sylvester, P.W. and Nazzal, S.  (2013)  “Vitamin E” fortified parenteral lipid emulsions: Plackett-Burman screening of primary process and composition parameters.  Drug Development and Industrial Pharmacy 39:363-373
133. Alayoubi, A., Kanthala, S., Satyanarayanajois, S.D., Anderson, J.F., Sylvester, P.W., and Nazzal, S.  (2013)  Stability and in vitro antiproliferative activity of bioactive “Vitamin E” fortified parenteral lipid emulsions.  Colloids and Surfaces B: Biointerfaces 103:23-30.  Doi:10.1016/j.colsurfb.2012.10.003
132. Alayoubi, A., Anderson, J.F., Satyanarayanajois, S.D., Sylvester, P.W., and Nazzal, S.  (2013)  Concurrent delivery of tocotrienols and simvastatin by lipid nanoemulsions potentiates their antitumor activity against human mammary adenocarcinoma cells.  European Journal of Pharmaceutical Sciences 48:385-392
131. Behery, F.A., Akl, M.R., Ananthula, S., Sylvester, P.W. and El Sayed, K.A.  (2013)  Optimization of tocotrienols as antiproliferative and antimigratory leads.  European Journal of Medicinal Chemistry 59: 329-341
130. Akl, M.R. and Sylvester, P.W. (2013) Anticancer Activity of Boswellia (Frankincense) Essential Oil. In: Recent Progress in Medicinal Plants, Volume 38, “Essential Oil III and Phytopharmacology, eds, J.N. Govil, pp 43-58. The Stadium Press LLC (USA), Houston, TX.
129. Malaviya, A. and Sylvester, P.W. (2013) Mechanisms mediating the effects of γ–tocotrienol used in combination with PPARγ agonists or antagonists on MCF-7 and MDA-MB-231 breast cancer cell proliferation. International Journal of Breast Cancer http://dx.doi.org/10.1155/2013/101705.
128. Alayoubi, A., Nazzal, M., Sylvester, P.W. and Nazzal, S. (2012) “Vitamin E” fortified parenteral lipid emulsions: Plackett-Burman screening of primary process and composition parameters. Drug Development and Industrial Pharmacy 39:363-373.
127. Akl, M.R., Ayoub, N.M., Abuasal, B., Kaddoumi, A and Sylvester, P.W. (2012) Sesamin synergistically potentiates the anticancer effects of g-tocotrienol in mammary tumor cell lines. Fitoterapia84C:347-359.
126. Alayoubi, A., Anderson, Satyanarayanajois, S.D., Sylvester, P.W., and Nazzal, S. (2012) Concurrent delivery of tocotrienols and simvastatin by lipid nanoemulsions potentiates their antitumor activity against human mammary adenocarcinoma cells. European Journal of Pharmaceutical Sciences 48:385-392.
125. Behery, F.A., Akl, M.R., Ananthula, S., Sylvester, P.W. and El Sayed, K.A. (2012) Optimization of tocotrienols as antiproliferative and antimigratory leads. European Journal of Medicinal Chemistry 59C: 329-341.
124. Alayoubi, A., Kanthala, S., Satyanarayanajois, S.D., Anderson, J.F., Sylvester, P.W., and Nazzal, S. (2012) Stability and in vitro antiproliferative activity of bioactive “Vitamin E” fortified parenteral lipid emulsions. Colloids and Surfaces B: Biointerfaces 103C: 23-30. Doi:10.1016/j.colsurfb.2012.10.003.
123. Akl, M.R., Ayoub, N.M., and Sylvester, P.W. (2012) Mechanisms mediating the synergistic anticancer effects of combined g-tocotrienol and sesamin treatment. Planta Medica 78:1731-1739. http://dx.doi.org/, 10.1055/s-0032-1315302.
122. Abuasal, B.S., Lucas, C., Peyton, B., Alayoubi, A., Nazzal, S., Sylvester, P.W., Kaddoumi, A. (2012) Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases γ-tocotrienol oral bioavailability. Lipids 47:461-469.
121. Abuasal, B.S., Qosa, H., Sylvester, P.W. and Kaddoumi, A. (2012) Comparison of the intestinal absorption and bioavailability of α-tocopherol and γ-tocotrienol: in-vitro, in-situ, and in-vivo studies. Drug Metabolism & Disposition 33:246-256.
120. Sylvester, P.W. Malaviya, A., Ananthula, S., Parash, P., and Tiwari, R.V. (2012) Statins as Anticancer Agents. In: Statins: Pharmacology, Clinical Implications and Adverse Effects, eds, Benedetta La Grua and Alessandro Molinelli, pp 125-150. Nova Science Publishers, Inc., Hauppauge, NY.
119. Nazzal, S. and Sylvester, P.W. (2012) Tocotrienol Loaded Lipid Nanoparticles in Cancer.  In: Nanomedicine and Cancer, eds, Rajaventhan Srirajaskanthan and Victor R. Preedy, pp 63-83. Science Publishers/CRC Press Taylor & Francis Group
118. Alayoubi, A., Satyanarayanjois, S.D., Sylvester, P.W., and Nazzal, S.M.  (2012)  Molecular Modeling and Multisimplex Optimization of Tocotrienol-Rich Self Emulsified Drug Delivery Systems.  International Journal of Pharmaceutics 426:153-161.
117. Ayoub, N.M., Bachawal, S.V. and Sylvester, P.W.  (2011)  g-Tocotrienol inhibits Met expression and activation in highly malignant mammary tumor cells.  Cell Proliferation 44: 516-526.
116. Abuznait, A.H., Qosa, H., O’Connel, N.D., Akbarian-Tefaghi, J., Sylvester, P.W., El Sayed, K.A., and Kaddoumi, A.  (2011)  Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products.  Food and Chemical Toxicology 49:2765-2772.
115. Sylvester, P.W.  (2012)  Synergistic Anticancer Effects of Combined g-Tocotrienol with Statin or Receptor Tyrosine Kinase Inhibitor Treatment in Mammary Tumor Cells.  Genes & Nutrition 7:63-74.
114. Shirode, A. B. and Sylvester, P. W. (2011).  Mechanisms mediating the synergistic anticancer effects of combined g-tocotrienol and celecoxib treatment.  Journal of Bioanalysis & Biomedicine 3:001-007. doi:10.4172/1948-593x.1000036.
113. Abuasal, B., Thomas, S., Sylvester, P.W., and Kaddoumi, A.  (2010)  Development and validation of a reversed phase HPLC method for the determination of γ-tocotrienol in rat and human plasma. Biomedical Chromatography doi: 10.1002/BMC.1493
112. Sylvester, P.W., Wali, V.B., Bachawal, S.V., Shirode, A.B., Ayoub, N.M., and Akl, M.R  (2011)  Synergistic anticancer response resulting from combined treatment of g-tocotrienol with other chemotherapeutic agents.  Frontiers in Bioscience  17:3183-3195
111. Mudit, M., Behery, F.A., Wali, V.B., Sylvester, P.W., and El Sayed, K.A.  (2010)  Synthesis of Fluorescent Analogues of the Anticancer Natural Products 4-Hydroxyphenylmethylene Hydantoin and d -Tocotrienol.  Natural Product Communications 5:1623-1626.
110. Sylvester, P.W., Kaddoumi, A., Nazzal, S., and El Sayed, K.A.  (2010)  Value of tocotrienol dietary supplementation in the prevention and treatment of breast cancer.  Journal of the American College of Nutrition. 29:324S-333S.
109. Sylvester, P.W.  (2011).  Precise Measurement of Viable Cell Number Using the MTT Colorimetric Assay.  In: Drug Design and Discovery: Methods and Protocols, eds. Seetharama S. Jois, pp 157-168.  Humana Press, New York, NY.
108. Sylvester, P.W., Akl, M.R. and Ayoub, N.M. (2011).  Tocotrienol Dietary Supplementation and Health.  In: Vitamin E: Nutrition, Side Effects and Supplements, eds, Alice E. Lindberg, pp 1-43.  Nova Science Publishers, Inc., Hauppauge, NY.
107. Abu Asal, B., Sylvester, P.W., and Kaddoumi, A.  (2010)  Intestinal absorption of g-tocotrienol is mediated by NPC1L1: in situ rat intestinal perfusion studies.  Drug Metabolism and Disposition 38:939-9445.
106. Ali, H., El Sayed, K. A., Sylvester, P.W., and Nazzal, S.  (2010)  Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: evidence studies by differential scanning calorimetry (DSC) and proton nuclear magnetic resonance spectroscopy (1H NMR)”, Colloids and Surfaces B: Biointerfaces. 77:286-297.
105. Mudit, M., Behery, F.A., Wali, V.B., Sylvester, P.W., and El Sayed, K.A.  (2010)  Toward molecular target identification of anticancer natural products: fluorescent coumarin tagging of 4-hydroxy-phenylmethylene hydantoin and g-tocotrienol.  Naural Product Communication 5:1623-1626.
104. Behery, F.A., Elnagar, A.Y., Akl, M.R., Wali, V.B., Abuasal, B., Kaddoumi, A., Sylvester, P.W. and El Sayed, K.A.  (2010) Tocotrienol redox-silent ester analogs as breast cancer proliferation and migration inhibitors.  Bioorganic & Medicinal Chemistry 18:8066-8075.
103. Sylvester, P.W., Ayoub, N.M., and Akl, M.R. (2010).  Role of Natural Vitamin E in Breast Cancer Prevention and Treatment.  In: Lipids: Categories, Biological Functions and Metabolism, Nutrition and Health, eds, Frank Columbo, Nova Science Publishers, Inc., Hauppauge, NY.  eds, Paige L. Gilmore, pp371-388. Nova Science Publishers, Inc., Hauppauge, NY.
102. Ali, H., Shirode, A., Sylvester, P.W., and Nazzal, S.  (2010)  Preparation, characterization, and anticancer effects of simvastatin-tocotrienol lipid nanoparticles.  International Journal of Pharmaceutics 289:223-231.
101. Bachawal, S.V., Wali, V.B., and Sylvester, P.W.  (2010)  Enhanced antiproliferative response to combined y-tocotrienol and erlotinib or gefitinib treatment in mammary tumor cells.  BioMedical Central Cancer 10:84. doi:10.1186/1471-2407-10-84.
100. Samant, G.V., Wali, V.B. and Sylvester, P.W.  (2010)  Antiproliferative effects of y-tocotrienol on mammary tumor cells are associated with a suppression in cell cycle progression.  Cell Proliferation 43:77-83.
99. Shirode, A.B. and Sylvester, P.W.  (2010)  Synergistic antiproliferative effect of y-tocotrienol and celecoxib on mammary tumor cells is associated with suppression in Akt and NFκB Signaling.  Biomedicine and Pharmacotherapy 64:327-332.
98. Bachawal, S.V., Wali, V.B., and Sylvester, P.W.  (2010)  Combined g-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in mammary tumor cells.  Anticancer Research 30:429-438.
97. Ali, H., Shirode, A., Sylvester, P.W., and Nazzal, S.  (2010)  Preparation and in vitro antiproliferative effect of tocotrienol loaded lipid nanoparticles.  Colloids and Surfaces A: Physicochemical and Engineering Aspects 353:43-51, 2009.
96. Elnagar, A.Y., Wali, V.B., Sylvester, P.W. and El Sayed K.A.  (2010)  Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion.  Bioorganic & Medicinal Chemistry 18:755-768.
95. Abdel Bar, F.M., Khanfar, M.A., Elnagar, A.Y., Badria, F.A., Zaghloul, A.M., Ahmad, K.F.,  Sylvester, P.W. and El Sayed, K.A.  (2010)  Design and pharmacophore modeling of microtubule-disrupting biaryl methyl eugenol analogs as breast cancer invasion inhibitors.  Bioorganic Medicinal Chemistry 18:496-507.
94. Wali, V.B., Bachawal, S.V., and Sylvester, P.W.  (2009)  Combined Treatment of g-Tocotrienol with Statins Induce Mammary Tumor Cell Cycle Arrest in G1.  Experimental Biology and Medicine 234: 639-650.
93. Abdel Bar, F. M., Khanfar, M.A., Elnagar, A.Y., Liu, H., Zaghloul, A M., Badria, F.A., Sylvester, P.W., Ahmad, K.F., Raisch, K.P., and El Sayed, K. A.  (2009)  Rational Design and Semisynthesis of Betulinic Acid Analogues as Potent Topoisomerase Inhibitors.  Journal of Natural Products 72:1643-1650.
92. Patwardhan, G.A., Zhang, Q-J., Yin, D., Gupta, V., Bao, J., Xie, P., Senkal, C.E., Ogretmen, B., Cabot, M.C., Shah, G., Sylvester, P.W., Jazsinski, S.M., and Liu, Y-Y.  (2009)  A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis.  PLoS ONE 4(9): e6938. doi:10.1371/journal.pone.0006938.
91. Wali, V.B., Bachawal, S.V., and Sylvester, P.W.  (2009)  Endoplasmic reticulum stress mediates g-tocotrienol-induced apoptosis in mammary tumor cells.  Apoptosis 14:1366-1377.
90. Wali, V.B., Bachawal, S.V. and Sylvester, P.W.  (2009)  Suppression in mevalonate synthesis mediates the antitumor effects of combined statin and g-tocotrienol treatment.  Lipids 44:925-934.
89. Sylvester, P.W., Samant, G.V., Wali, V.B., and Bachawal, S.V.  (2009).  Intracellular Mechanisms Mediating Vitamin E Suppression of Mammary Tumor Cell Proliferation.  In:  Handbook of Cell Proliferation, eds. Andre P. Briggs and Jacob A. Coburn, 371-388.  Nova Science Publishers, Inc., Hauppauge, NY.
88. Abdel Bar, F. M., Zaghloul, A.; Bachawal, S,V. Sylvester, P.W. Khanfar, M. and El Sayed, K.  (2008)  Antiproliferative Triterpenes from Melaleuca ericifolia.  Journal of Natural Products  71:1787-1790.
87. Radwan, M.M., Manly, S.P., El Sayed, K.A., Wali, V.B., Sylvester, P.W., Awate, B., Shah, G., Ross, S.A.  (2008)  Sinulodurins A and B, Antiproliferative and Anti-invasive Diterpenes from the Soft Coral Sinularia dura.  Journal of Natural Products 71:1468-1471.
86. Sylvester, P.W., Bachawal, S. V., Wali, V.B., and  Shirode, A. B. (2008) Epidermal Growth Factor Receptor Dependent Mitogenic Signaling in Normal and Maligant Mammary Epithelial Cells. In: Cellular Growth Processes, ed. Daiki Kimura, 139-157, Nova Science Publishers, Inc., Hauppauge, NY.
85. Sylvester, P.W. (2008) Antiproliferative and Apoptotic Effects of Tocotrienols on Normal and Neoplastic Mammary Epithelial Cells. In: Tocotrienols: Vitamin E Beyond Tocopherols, eds. Ronald R. Watson, 119-140 AOCS Press, Champaign, IL.
84. El Sayed, K., Laphookhieo, S., Yousaf, M., Prestridge, J., Shirode, A.B., Wali, V. B., and Sylvester, P.W. (2008) Semisynthetic and biocatalytic anticancer optimization of tobacco (1S, 2E, 4S, 6R, 7E, 11E)-2,7,11-cembratriene-4,6-diol. Journal of Natural Products 71:117-122.
83. Wali, V.B. and Sylvester, P.W. (2007) Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells.  Lipids 43:1113-1123.
82. Sylvester, P.W. (2007). Vitamin E and Apoptosis. In: Vitamins and Hormones, Volum 76, ed. G Litwack, 329-356. Elsevier Inc, San Diego, CA.
81. Sylvester, P.W.  (2007).  Mechanisms Mediating Vitamin E-Induced Apoptosis in Mouse Mammary Tumors.  In: New Cell Apoptosis Research, eds. Lindsey C. Vinter, 53-66. Nova Science Publishers, Inc., Hauppauge, NY .
80. Sylvester, P.W., Wali, V.B., Shirode, A.B., Bachawal, S.V., and El Sayed, K.A. (2007) Tocotrienols Are the Most Potent Anticancer Agents in the Vitamin E Family of Compounds.  Current Research in Cancer 1:55-75.
79. El Sayed, K.A. and Sylvester P.W. (2007) Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids.  Expert Opinions on Investigational Drugs  16: 877-887
78. Jain, S., Shirode, A., Yacoub, S., Barbo, A., Sylvester, P.W., Huntimer, E., Halaweish, F., and El Sayed, K.A. 2007  Biocatalysis of the anticancer sipholane triterpenoids.  Planta Medica  73: 1-6.
77. Sawant, S.S., D. T.A. Youssid, P. W. Sylvester, V. Wali, and K. A. El Sayed 2007  Antiproliferative sesquiterpenes from the Red Sea soft coral Sarcophyton glaucum.  Natural Product Communications  2:117-119.
76. Sylvester, P.W.  2006.  Targeting the PI3K/PDK/Akt Signaling Pathway in Anticancer Therapy.  In: Trends in Signal Transduction Research, eds. Jennifer N. Meyer, 173-190.  Nova Science Publishers, Inc., Hauppauge, NY
75. Samant, G.V., and P. W. Sylvester.  2006 Gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signaling in of neoplastic mammary epithelial cells.  Cell Proliferation 39:563-574.
74. Sawant, S., D. Youssef, A. Mayer, P. Sylvester, V. Wali, M. Arant, and K. El Sayed.  2006  Anticancer and anti-inflammatory sulfur-containing semisynthetic derivatives of sarcophine.  Chemical and Pharmaceutical Bulletin 54:1119-1123.
73. Sylvester, P. W., and Shah, S. J. (2005) Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells. Asian Pacific Journal of Clinical Nutrition 14:366-373.
72. Sylvester, P. W., Shah, S. J., Haynie, D. T., and Briski, K. P. (2005) Effects ofultra-wideband electromagnetic pulses on preneoplastic mammary epithelial cell proliferation. Cell Proliferation 38:153-163.
71. Sylvester, P. W., Shah, S. J., and Samang, G. V. (2005) Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of gamma-tocotrienol in neoplastic mammary epithelial cells. Journal of Plant Physiology 162:803-810.
70. Shah, S. J., and Sylvester, P. W. (2005) Antiproliferative effects of gamma-tocotrienol are associated with a reduction in Akt and NFkB activity. Experimental Biology and Medicine 230:235-241.
69. Shah, S. J., and Sylvester, P. W. (2005) Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. Biochemistry and Cell Biology 83:86-95.
68. Singh, S. R., Sylvester, P. W., and Briski, K. P. (2004) Caudal hindbrain glucoprivation enhances GABA release in discrete septopreoptic structures in the steroid-primed ovariectomized rat brain: role of mu opiod receptors. Neuroendocrinology 80:201-209.
67. Sawant, S. S., Sylvester, P. W., Avery, M. A., Desai, P., Youssef, T. A., El Sayed, K. A. (2005) Bioactive rearranged and halogenated semmisynthetic derivatives of the marine natural product sarcophine. Journal of Natural Products 67:2017-2023.
66. Sylvester, P. W. and Shah, S. J. (2005) Mechanisms nediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells. Frontiers in Bioscience 10:599-609.
65. Shah, S. J. and Sylvester, P. W. (2004) Tocotrienol-induced caspase-8 activation occurs independently of death receptor apoptotic signaling in malignant mammary epithelial cells. Experimental Biology and Medicine 229:745-755.
64. Sylvester, P. W. and Shah, S. J. (2004) Potential health benefits of palm tocotrienols in the prevention and treatment of breast cancer. Palmas 25:233-244.
63. Cooke, P. S., Holsberger, D. R., Witorsch, R. J., Sylvester, P. W., Meredith, J. M., Treinen, K. A., and Chapin, R. E. (2004) The influence of non-reproductive hormones on the reproductive system. Toxicology and Applied Pharmacology 194:309-335.
62. Shah, S. J., Gapor, A., and Sylvester P. W. (2003) Tocotrienol-induced apoptosis is mediated through caspase-8 activation in neoplastic mouse mammary epithelial cells. Nutrition and Cancer 45:236-246.
61. Sylvester, P. W. and Theriault, A. (2003) Role of tocotrienols in the prevention of cardiovascular disease and breast cancer. Current Topics in Nutraceutical Research 1:121-135.
60. Sylvester, P. W., Nachnani, A., Shah, S., and Briski, K. P. (2002) Role of GTP-binding proteins in reversing the antiproliferative effects of tocotrienols in preneoplastic mammary epithelial cells. Asian Pacific Journal of Clinical Nutrition 11:S452-S459.
59. Sylvester, P. W. and Shah, S. (2002) Antioxidants in dietary oils: their potential role in breast cancer prevention. Malaysian Journal of Nutrition 8:1-11.
58. Sorg, B. A., Davidson, D. L., Hochstatter, T., and Sylvester, P. W. (2002) Repeated cocaine decreases the avoidance response to a novel aversive stimulus in rats. Psychopharmacology 163:9-19.
57. Sylvester, P. W., McIntyre, B. S., Gapor, A., and Briski, K. P. (2001) Vitamine E inhibition of normal mouse mammary epithelial cell growth is associated with a reduction in protein kinase C-alpha activation. Cell Proliferation 34:347-358.
56. Sylvester, P. W. (2001) Tocopherol and tocotrienol effects on normal mammary epithelial cell growth and proliferation. In: Micronutrients and Health: Molecular Biological Mechanisms, eds. K. Nesaretnam and L. Pakcer, 332-345. AOCS Press, Champaign, IL.
55. Briski, K. P., Marshall, E. S., and Sylvester, P. W. (2001) Effects of estradiol on glucoprivic transactivation of catecholaminergic neurons in the female rat caudal brainstem. Neuroendocrinology 73:369-377.
54. Briski, K. P. and Sylvester, P. W. (2001) Co-distribution of Fos- and mu opiod receptor immunoreactivity within the rat septopreoptic area and hypothalamus during acute glucose deprivation: effects of the mu receptor antagonist CTOP. Neuroscience Letters 306:141-14.
53. Briski, K. P., and Sylvester, P. W. (2001) Hypothalamic orexin-A-immunpositive neurons express Fos in response to central glucopenia. Neuroreport 12:531-534.
52. McIntyre, B. S., Briski, K. P., Gapor, A., and  Sylvester, P. W. (2000) Antiproliferative and apoptotic effects of tocopherols and tocotrienols in preneoplastic and neoplastic mammary epithelial cells. Proceedings of the  Society of Experimental Biology and Medicine 224:292-301.
51. McIntyre, B. S., Briski, K. P., Tirmenstein, M., Fariss, M. W., Gapor, A. and
Sylvester, P. W. (2000) Antiproliferative and apoptotic effects of tocopherols and tocotrienols in normal mouse mammary epithelial cell. Lipids 35:171-180.
50. Mealey, K. L., Barhoumi, R., Burghard, R. C., McIntyre, B. S., Sylvester, P. W., Hosick, H. L. and Kochevar, D. T. (1999) Immunosuppressant inhibition of P-glycoprotein function is independent of drug-induced suppression of peptide-prolyl isomerase and calcineruin activity. Cancer Chemotherapy and Pharmacology 44:152-158.
49. Briski, K. P., and Sylvester, P. W. (1999) Site-specific induction of Fos immunoreactivity in preoptic and hypothalamic NADPH-positive neurons during glucoprivatioin. Neuroendocrinology 69:181-190.
48. Briski, K. P. and Sylvester, P. W. (1998) Role of endogenous opiates in glucoprivic inhibitioin of the LH surge and Fos expression by preoptic GnRH neurons in ovariectomized, steroid-primed female rats. Journal of Neuroendocrinology 10:769-776.
47. Robison, L. M., Sylvester, P. W., Birkenfeld, H. P., Lang, J. P., and Bull, R. J. (1998) Comparison of the effects of iodine and iodide in thyroid function in humans. Journal of Toxicology and Environmental Health 55:93-106.
46. McIntyre, B. S., and Sylvester, P. W. (1998) Genistein and erbstatin inhibition of normal mammary epithelial cell proliferation is associated with EGF-receptor down-regulation. Cell Proliferation 31:35-46
45. McIntyre, B. S., Briski, K. P., Hosick, H. L., and Sylvester, P. W. (1998) Effect of tyrosine phosphatase inhibitors on EGF- and insulin-dependent mammary epithelial cell growth. Proceedings of the Society of Experimental Biology and Medicine 217:180-187.
44. Birkenfeld, H. P., McIntyre, B. S., Briski, K. P., and Sylvester, P. W. (1996) Protein kinase C isoenzymes expression in normal mouse mammary epithelial cells grown in primary culture. Proccedings of the Society of Experimental Biology and Medicine 213:65-70.
43. Briski, K. P., Swanson, G. N., and Sylvester, P. W. (1996) Size and charge heterogeneity of pituitary and plasma prolactin in male rats. Neuroendocrinology 63:437-445.
42. Birkenfeld, H. P., McIntyre, B. S., Briski, K. P., and Sylvester, P. W. (1996) Role of pritein kinase C in modulating epidermal growth factor and phorbol ester-induced mammary epithelial cell growth. Experimental Cell Research 223:183-191.
41. McIntyre, B. S., Birkenfeld, H. P. and Sylvester, P. W. (1995) Relationship between epidermal growth factor receptor levels, autophosphorylation and mitogenic-responsiveness in normal mouse mammary epithelial cells in vitro. Cell Proliferation 28:45-56.
40. Briski, K. P. and Sylvester, P. W. (1994) Antagonism of type II, but not type I, glucocorticoid receptors results in elevated basal LH release in male rats. Neuroendocrinology 60:601-608.
39. Sylvester, P. W., Birkenfeld, H. P., Hosick, H. L. and Briski, K. P. (1994) Fatty acid modulation of epidermal growth factor-induced mouse mammary epithelial cell proliferation in vitro. Experimental Cell Research 214:145-153.
38. Sylvester, P. W., Ip, M. M. and Briski, K. P. (1993) Effects of specific fatty acid on prolactin-induced Nb2 lymphoma cell proliferation. Life Sciences 52:1977-1984.
37. Briski, K. P. and Sylvester, P. W. (1992) Differential impact of naltrexone on luteinizing hormone release during single versus repetitive exposure to restraint stress. Psychoneuroendocrinology 17:125-133.
36. Briski, K. P. and Sylvester, P. W. (1992) Inhibition of pituitary bioactive prolactin secretion in the male rat by the glucocorticoid agonist decadron phosphate. Biology of Reproduction 47:478-484.
35. Briski, K. P. and Sylvester, P. W. (1991) Acute inhibition of pituitary LH release in the male rat by the glucocorticoid agonist decadron phosphate. Neuroendocrinology 54:313-320.
34. Briski, K. P. and Sylvester, P. W. (1991) Effect of naltrexone on stress-induced bioactive prolactin release in aging male rats. Neurobiology of Aging 12:145-149.
33. Briski, K. P. and Sylvester, P. W. (1990) Comparative effects of various stressors on immunoreactive versus bioactive prolactin release in old and young male rats. Neuroendocrinology 51:625-631.
32. Sylvester, P. W., and Briski, K. P. (1990) Diminished bioactivity of circulating prolactin despite increased immunoreactive hormone release in old versus young male rats. Endocrinology 126:746-753.
31. Isseroff, H., Sylvester, P. W., Bessette, P. L., Jones, P. L., Fisher, W. G., Rynkowski, T. A., and Gregor, K. R. (1989) Schistosomiasis: role of endogenous opiods in suppressioni of gonadal steroid secretion. Comparative Biochemical Physiology 94A(1):41-45.
30. Sylvester, P. W., Forczek, S., Ip, M. M., and Ip., C. (1989) Relation of exercise training to the differential prolactin secretory response in male and female rats. Journal of Applied Physiology 67:804-810.
29. Sylvester, P. W., Ult, P. J., and Ip, M. M. (1988) Effects of the thiazolidinedione derative CGP-19984 (methoxonyl) on growth and endocrine function of the MtT-W10 transplantable mammosomatotropic pituitary tumor in female rats. International Journal of Cancer 42:289-294.
28. Briski, K. P. and Sylvester, P. W. (1988) Effects of specific acute stressors on LH release in ovariectomized and ovariectomized estrogen-treated female rats. Neuroendocrinology 47:194-202.
27. Briski, K. P. and Sylvester, P. W. (1987) Effects of repetitive daily acute stress on pituitary LH an dprolactin release during exposure to the same stressor or a second novel stress. Psychoneuroendocrinology 12:429-438.
26. Briski, K. P., and Sylvester, P. W. (1987) Effects ofsequential acute stress exposure on stress-induced pituitary luteinizing hormone and prolactin secretion. Life Sciences 41:1249-1255.
25. Sylvester, P. W., and Ip, M. M. (1987) Role of prolactin in modulating the effects of tamoxifen on the growth of the Dunning R3327 rat prostatic adenocarcinoma. The Prostate 10:57-67.
24. Ip, C., Ip, M. M. and Sylvester, P. W. (1986) Relevance of trans fatty acids and fish oil in animal tumorigenesis studies. In: Dietary Fat and Cancer, eds. A. Rogers, D. Birt, C. Mettlin and C. Ip, 283-294. Alan R Liss, Inc. New York.
23. Sylvester, P. W. (1986) Role of acute underfeeding in murine tumorigenesis. In: Dietary Fat and Cancer. eds. A. Rogers, D. Birt, C. Mettlin and C. Ip, 517-528. Alan R. Liss, Inc., New York.
22. Isseroff, H., Sylvester, P. W., and Held, W. A. (1986) Schistosomiasis: Effect of andorgen-regulated gene expression in the mouse. Molecular and Biochemical Parasitology 18:401-402.
21. Ip, M. M., Sylvester, P. W., and Schenkel, L. (1986) Antitumor efficacy of CGP 19984, a thiazolidinedione derivative with LH inhibiting activity. Cancer Research 46:1735-1740.
20. Sylvester, P. W., Ip, C., and Ip, M. M. (1986) Effects of high dietary fat in the growth and development of hormone-independent carcinogen-induced mammary tumors in rats. Cancer Research 46:763-769.
19. Sylvester, P. W., Russell, M., Ip, M. M., and Ip, C. (1986) Comparative effects of different animal and vegetable fats fed before an dduring carcinogen administration on tumorigenesis, sexual maturation and endocrine function in rats. Cancer Research 46:757-762.
18. Sylvester, P. W., and Ip, M. M. (1985) Effects of indomethacin on plasma prolactin and mammary gland prolactin receptors in rats fed normal and high fat diets. IRCS Medical Science 13:1203-1204.
17. Sylvester, P. W., Sarkar, D. K, Briski, K. P., and Meites, J. (1985) Relation of gonadal hormones to differential LH response to naloxone in prepubertal male and female rats. Neuroendocrinology 40:165-170.
16. Chen, H. T., Sylvester, P. W., Steger, R. W., and Meites, J. (1984) Effects of adrenalectomy and 5-hydroxytryptophan on phasic release of LH. Life Sciences 34:743-749.
15. Aylsworth, C. F., Van Vugt, D. A., Sylvester, P. W., and Meites, J. (1984) Failure of high dietary fat to influence serum prolactin levels during the estrous cycle in female Sprague-Dawley rats. Proceedings of the Society for Experimental Biology and Medicine 175:25-29.
14. Aylsworth, C. F., Van Vugt, D. A., Sylvester, P. W., and Meites, J. (1984) Role of estrogen and prolactin in high fat stimulation of development of carcinogen-induced mammary tumors. Cancer Research 44:2835-2840.
13. Meites, J., Van Vugt, D. A., Forman, L. J., Sylvester, P. W., Leiri, T., and Sonntag, W. (1983) Evidence that endogenous opiates are involved in control of gonadotropin secretion. In: The Anterior Pituitary Gland, ed. A. S. Bhatnager, 327-340. Raven Press, New York.
12. Sylvester, P. W., Aylsworth, C. F., Van Vugt, D. A., and Meites, J. (1983) Effects of alterations in early hormonal environment on development and hormone-dependency of carcinogen-induced mammary tumors in rats. Cancer Research 43:5342-5346.
11. Sylvester, P. W., Aylsworth, C. F., Van Vugt, D . A., and Meites, J. (1982) Influence of underfeeding during the "critical period" or thereafter on carcinogen-induced mammary tumors in rats. Cancer Research 42:4943-4947.
10. Sylvester, P. W., Van Vugt, D. A., Sylsworth, C. A., Hanson, E. A., and Meites, J. (1982) Effects of morphine and naloxone on inhibition by ovarian hormones of pulsatile release of LH in ovariectomized rats. Neuroendocrinology 34:269-273.
9. Van Vugt, D. A., Sylvester, P. W., Aylsworth, C. A., and Meites, J. (1982) Counteraction of gonadal steroid inhibition of luteinizing hormone release by naloxone. Neuroendocrinology 34:274-278.
8. Van Vugt, D. A., Aylsworth, C. F., Sylvester, P. W., Leung, F. C., and Meites, J. (1981) Evidence for hypothalamic noradrenergic involvement in naloxone-induced stimulation of luteinizing hormone release. Neuroendocrinology 33:261-264.
7. Van Vugt, D. A., Sylvester, P. W., Aylsworth, C. F., and Meites, J. (1981) Comparison of acute effects of dynorphin and beta-endorphin on prolactin release in the rat. Endocrinology 108:2017-2019.
6. Sylvester, P. W., Aylsworth, C. F., and Meites, J. (1981) Relationship of hormones to inhibition of mammary tumor development by underfeeding during the "critical period" after carcinogen administration. Cancer Research 41:1384-1388.
5. Chen, H. T., Sylvester, P. W., Leiri, T., and Meites, J. (1981) Potentiation of luteinizing hormone release by serotonin agonists in ovariectomized steroid primed rats. Endocrinology 108:948-952.
4. Aylsworth, C. F., Sylvester, P. W., Leung, F., and Meites, J. (1980) Inhibition of mammary tumor growth by dexamethasone in rats in the presence ofhigh serum prolactin levels. Cancer Research 40:1863-1866.
3. Sylvester, P. W., Chen, H. T., and Meites, J. (1980) Effects of morphine and naloxone on the phasic release of gonadotropins. Proceeding of the Society for Experimental Biology and Medicine 164:207-211.
2. Van Vugt, D. A., Bruni, J. F., Sylvester, P. W., Chen, J. T. Leiri, T., and Meites, J. (1979) Interaction between opiates and hypothalamic dopamine on prolactin release. Life Sciences 24:2361-2368.
1. Sylvester, P. W., Chen, H. T., and Meites, J. (1978) Interactions of morphine and dopaminergic and cholinergic drubs on release of prolactin in the rat. IRCS Medical Sciences 6:510.

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