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The following presentations are scheduled: Tu, February 22, 2011 Presentation by Dr. Joshua Lawrence: “Perfluoroalkylation of arenes: Scope, mechanism, and synthesis of analgesic derivatives” (Carver Hall 217, Grambling State University) Abstract: Fluorinated organic molecules comprise over 20% of pharmaceuticals and 40% of agrochemicals. The application of fluoroorganics to various biological problems has been encouraged by their favorable properties, including increased stability and lipophilicity in vivo. Although several methods to install perfluoroalkyl groups on arene rings have been described, no one general method for mild, efficient, tolerant perfluoroalkyl transfer has been described. The recent Pd-catalyzed perfluoroalkylation reaction described by the Buchwald group, for example, has a broad scope and is reasonably mild but still requires the use of aryl halides. C-H bond activation could provide a route for direct and atom-economical synthesis of perfluoralkyl arenes. Some systems capable of perfluoroalkylating arenes via C-H activation are known, although all require reagents that are difficult to synthesize, suffer from limited substrate scope, or give poor yields. It is also known that compounds of the formula Fe(CnF2n+1)(I)(CO)4 transfer perfluoroalkyl ligands to arenes and heteroarenes upon reaction with AgF, although the yields and selectivities for the perfluoroalkyl transfer reactions are not acceptable for synthetic applications. We have developed reaction conditions that allow the use of Fe(CnF2n+1)(I)(CO)4 for perfluoroalkylation in reasonable yields. Our work to determine the scope and mechanism of this reaction will be described, as well as the application of this reaction to the synthesis of perfluoroalkyl analogues of common analgesics. Tu, April 12, 2011 Presentation by Dr. David Wipf, Mississippi Statue U. (ULM, time, location and topic TBA) We plan to host two additional speakers this fall, times and topics TBA. Ouachita Valley Section Officers
Please direct any e-mail to our local section's webmaster, Dr. Thomas Junk, junk@ulm.edu Many members of our section are affiliated with one of four regional universities, all of which are home to chemistry and chemistry-related programs. University of Arkansas-Monticello: http://www.uamont.edu The U.S. National Olympiad (USNCO) is a multi-tiered competition designed to stimulate and promote achievement in high school chemistry. This year's time table has been posted. We encourage participation in the annual ACS Chemistry Olympiad. Interested participants should please contact one of the Ouachita Valley Section's regional officers for more information. National Chemistry Week and Earth Day After the success of previous Earth Day activities, our section joined the City of Monroe Earth Day celebration this year with a booth. We displayed interactive water purification/water testing equipment to a crowd of visitors ( see photos!). Please join us in celebrating National Chemistry Week this fall. |
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