- E. coli
- E-commerce
- Ear piercings
- Earth Day
- Earthquakes
- Eating disorders
- Ebola virus
- Ebonics
- Ecclesiarchy
- Ecoterrorism
- Ecology
- Ecological warfare
- Ecstacy (as in the illegal drug)
- Elective surgery
- Electric cars
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- Electroshock therapy
- Elopement
- Endangered species (or a specific one)
- Energy crisis
- Environment
- Epidemics
- Ergonomics
- Ethics (maybe in your major, like nursing ethics)
- Eugenics
- Euthanasia
- Evolution
- Exercise
- Extrasensory perception (ESP)
- Extraterrestrial life
- Extreme sports
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