- Safe sex practices
- Salem witch trials
- Salt
- Same sex marriage (also called civil unions)
- Santa Claus
- Saudi Arabia
- Schizophrenia
- School bus safety
- School shootings/school violence
- School uniforms
- Scientology
- Seaweed
- Secret Service
- Self-defense
- September 11th
- Serial killers
- Sex change operation
- Sex education
- Sexual discrimination
- Sexual harassment
- Sexual offenders/predators
- Sexually transmitted diseases
- Sharks
- Shoplifting
- Siblings
- Sickle Cell Disease
- Sikhism
- Skiing (snow or water)
- Skydiving
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- Slam poetry
- Sleep deprivation
- Smithsonian Institute
- Social networks/networking (like Facebook)
- Social Security
- Socialism
- Space elevator
- Space exploration
- Special Olypmics
- Speed limits
- Spiders
- Spies
- Splenda
- St. John's Wort
- Stalking
- Standardized testing
- Starbucks
- Steroids
- Stock market
- Stress
- Student loans
- Student rights
- Substance abuse
- Sugar/sugar substitutes (like Splenda!)
- Suicide
- Support groups (grief, survivor, cancer, etc.)
- Surfing
- Sushi
- Sweat shops
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