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College of Pharmacy
School of Basic Pharmaceutical and Toxicological Sciences

Dr. Paul Sylvester's Research Interests

Currently our laboratory is characterizing the intracellular mechanisms mediating the antiproliferative and cytotoxic effects of tocotrienols in isolated normal, preneoplastic and neoplastic mouse mammary epithelial cells. Tocotrienols and tocopherols represent the two subgroups of compounds that make up the Vitamin E family.  However, experimental evidence indicates that tocotrienols have significantly greater anticancer activity than tocopherols, suggesting that tocotrienols may have significant value as therapeutic agents for breast cancer prevention and/or treatment.

The chemoprotective effects of tocotrienols are of particular interest because these compounds attenuate growth factor-induced mitogenesis and induce apoptosis at significantly lower doses in tumor versus normal mammary epithelial cells. Characterization of the intracellular mechanism(s) of action of tocotrienols would provide essential information necessary for understanding the potential health benefits of these compounds in preventing and/or reducing the risk of breast cancer in women.

Contact Information

Dr. Paul Sylvester Paul W. Sylvester, Ph.D.
B. J. Robison/Pfizer Endowed Professor
Professor of Pharmacology
Bienville 344
School of Basic Pharmaceutical & Toxicological Sciences
College of Pharmacy
University of Louisiana at Monroe
Monroe, LA 71209-0497
ph: 318-342-1958
fax: 318-342-1737
email:  sylvester@ulm.edu