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College of Pharmacy
School of Basic Pharmaceutical and Toxicological Sciences

Publications of Dr. Sharon Meyer

Original Peer-Reviewed Research Articles and Reviews

37. Ramasahayam S., S. Jaligama, S.M. Atwa, B.L. Blaylock and S.A. Meyer.  Megakaryocyte expansion and macrophage infiltration with MNX, N-nitroso environmental degradation product of munitions compound RDX (hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine), in bone marrow of subchronically exposed rats (submitted)
36. Wilbanks, M.S., K.A. Gust, S.Atwa, I. Sunesara, D. Johnson, C.Y. Ang, S.A. Meyer, and E.J. Perkins. Validation of a genomics-based hypothetical adverse outcome: 2,4-dinitrotoluene perturbs PPAR signaling thus impairing energy metabolism and exercise endurance. Toxicol. Sci. (in press). PMID:24893713
35. Sallam, A. A., Mohyedin, M.M., Foudah,. A.I., Ak, M.R., Nazzal,S.M., Meyer, S.A., Liu. Y.Y. and El Sayed. K.A. Marine Natural Products-Inspired Phenylmethylene Hydantoins with Potent in Vitro and in Vivo Antitumor Activities via Suppression of Brk and FAK Signaling. Org. & Biomol. Chem. 12:5295-303, 2014
34. Akl M.R., Foudah, A.I., Ebrahim, H.Y., Meyer,S.A. and El Sayed, K.A. Marine-Derived 4′,5′-Dichlorobenzoyl Sipholenol A Inhibits Breast Cancer Cell Growth and Motility in vitro and in vivo through Suppression of Brk and FAK Signaling. Marine Drugs 12:2282-304, 2014
33. Sallam, A.A., Nayoub,N., Foudah,A.I., Gissendanner,C.R., Meyer,S.A. and El Sayed. K.A.  Indole diterpene alkaloids as novel inhibitors of the wnt/β-catenin pathway in breast cancer cells. European JMed. Chem. 70:594-606, 2013
32. Meyer S.A. and R.L. Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2B expression.  Sci Signal. 6(274):pe16, 2013 
Abstract             Full Text
31. Jaligama,S.,V.M.Kale, M.S. Wilbanks, E.J. Perkins and S.A.Meyer. Delayed myelosuppression with acute exposure to hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and environmental degradation product hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) in rats, Toxicol. Appl. Pharmacol. 266:443-451. 2013
30. Bhinge, K., V. Gupta, S. Hosain. S.D. Satyanarayanajois S.A.Meyer, B. Blaylock. Q.J. Zhang, and Y.Y. Liu.The opposite effects of doxorubicin on bone marrow stem cells versus breast cancer stem cells depend on glucosylceramide synthase. Int. J. Biochem. Cell Biol. 44:1770-1778, 2012 
29. Ramasahayam, S., H.N. Baraka, F.N. Abdel Bar, M.P. Widrlechner, K.A. El Sayed and S.A. Meyer. Effects of chemically characterized fractions from aerial parts of Echinacea purpurea and angustifolia on myelopoiesis in rats.Planta Med. 77:1883-9, 2011. 
28. Deng, Y., S.A.Meyer, X. Guan, B.L.Escalon, J. Ai, M.S. Wilbanks, R. Welti, N.G. Reyero, and E.J. Perkins. Analysis of common and specific mechanisms of liver function affected by nitrotoluene compounds. PLoS One 6(2):e14662, 2011. 
27. Chowbina, S, Y. Deng, J. Ai, X. Wu, X. Guan, M.S. Wilbanks, B.L. Escalon, S.A. Meyer, E.J. Perkins and J.Y. Chen. A new approach to construct pathway connected networks and its application in dose responsive gene expression profiles of rat liver regulated by 2,4DNT. BMC Genomics 11(Suppl 3):S4-11, 2010. 
26. Sallam A.A., S. Ramasahayam, S.A.Meyer and K.A. El Sayed.  Design, synthesis, and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration. Bioorganic & Medicinal Chem. 18:7446-57, 2010. 
25. Kale, V.M., S.R. Miranda, M.S. Wilbanks and S.A. Meyer.  Comparative cytotoxicity of chloroacetanilide herbicides alachlor, acetochlor and metolachlor in rat and cryopreserved human hepatocytes. J. Biochem. Mol. Toxicol. 22:41-50, 2008. 
24. Miranda, S. R., and Meyer, S. A. (2007) Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem. Toxicol. 45:871-877.
23. Perkins, E., Bao, W., Guan, X., Ang, C. Y., Wolfinger, R. D., Chu, T. M., Gong, P., Meyer, S. A., and Inouye, L. (2006) Comparison of gene expression effects in liver tissue and primary hepatocyte cell cultures after exposure to hexahydro-1,3,5-trinitro-1,3,5-triazine. BMC Bioinformatics 7 (Suppl. 4):S22-28.
22. Meyer, S. A., Marchand, A. J., Hight, J. L., Roberts, G. H., Inouye, L. S., Escalon, L. B. and MacMillan, D. K. (2005) Up-and-down procedure (UDP) determination of acute toxicity of nitroso degradation products of hexahydro-1,3,5-trinitro-1,3,5-triazine. J Appl. Toxicol. 25:427-434.
21. Dalton, S. R., Miller, R. T., and Meyer, S. A. (2003) Hervicide metolachlor induces liver cytochrome P450s 2B1/2 and 3A1/2, but not thyroxine-uridine dinucleotide phosphate glucuronosyltransferase and associated thyroid gland activation. Int. J. Toxicol. 22:287-295.
20. Dalton, S. R., Jirtle, R. L. and Meyer, S. A. (2000) EGF receptors of hepatocytes from rats treated with phenobarbital are sensitized to down-regulatioin by phenobarbital in culture. Toxicol. Appl. Pharmacol. 165:115-126.
19. Wetmore, B. A., Mitchell, A. D., Meyer, S. A., and Genter, M. B. (1999) Evidence for site-specific bioactivatioin of alachlor in the olfactory mucosa of the Long Evans rat. Toxicol. Sci. 49:202-212.
18. Goodell, A. L., Oh, H. S., Meyer, S. A., and Smart, R. C. (1996) Epidermal protein kinase C-B2 is highly sensitive to downregulation and is exclusively expressed in Langerhans cells: Downregulatioin is associated with attenuated contact hypersensitivity. J. Invest. Dermatol. 107:354-359.
17. Meyer, S. A., Kim, T. W., Moser, G. J., Monteiro-Riviere, N. M., and Smart, R. C. (1994) Synergistic interaction between the non-phobol ester-type promoter mirex and 12-O-tetradecanoylphorbol-13-acetate in mouse skin tumor promotion. Carcinogenesis 15:47-52.
16. Meyer, S. A., Moser, G. J., Monteiro-Riviere, N. A., and Smart, R. C. (1993) Minimal role of enhanced cell proliferation in skin tumor promotion by mirex, a new nonphorbol ester-type tumor promoter. Environ. Health Persp. 101 (Suppl 5):265-270.
15. Wasserman, R. H., Chandler, J. S., Meyer, S. A., Smith, C. A., Brindak, M. E., Fullmer, C. S., Penniston, J. T., and Kumar, R. (1992) Intestinal calcium transport and calcium extrusion processes at the basolateral membrane. J. Nutri. 12:662-671.
14. Moser, G. J., Meyer, S. A., and Smart, R. C. (1992) The chlorinated pesticide mirex is a novel non-phorbol ester tumor promoter in mouse skin. Cancer Res. 52:631-636.
13. Jirtle, R. L., Meyer, S. A., and Brockenbrough, J. S. (1991) Liver tumor promoter phenobarbital: A biphasic modulator of hepatocyte proliferation. Prog. Clin. Biol. Res. 369:209-216.
12. Jirtle, R. L. and Meyer, S. A. (1991) Liver tumor promotion: Effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-B1 expression. Digestive Diseases and Sci. 36:659-668.
11. Brockenbrough, J. S., Meyer, S. A., Li, C., and Jirtle, R. L. (1991) A reversible and phorbol ester-specific defect of protein kinase C translocation in hepatocytes isolated from phenobarbital-treated rats. Cancer Res. 51:130-136.
10. Meyer, S. A., Gibbs, T. A., and Jirtle, R. L. (1989) Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoyl-phorbol-13-acetate in reduction of hepatocyte EGF receptors. Cancer Res. 49:5907-5912.
9. Meyer, S. A., Ingraham, C. A., and McCarthy, K. D. (1989) Expression of vimentin by cultured astroglia and oligodendroglia. J. Neurosci. Res. 24:251-259.
8. Meyer, S. A., and Jirtle, R. L. (1989) Phenobarbital decreases EGF receptor expression by cultured hepatocytes independent of protein kinase C. Biochem. Biophys. Res. Commun. 158:652-569.
7. Meyer, S. A., Lin, Z., and Liu, A. Y. C. (1988) Neurite extension and increased expression of RI cAMP-binding protein in ouabain resistant neuroblastoma mutants. J. Neurochem. 51:950-959.
6. Eckl, P. M., Meyer, S. A., Whitcomb, W. R., and Jirtle, R. L. (1988) Phenobarbital reduces EGF receptors and the ability of physiological concentrations of calcium to suppress hepatocyte proliferation. Carcinogenesis 9:479-483.
5. Wasserman, R.H., H.J. Armbrecht, F. Shimura, S. Meyer, J.S. Chandler. Vitamin D influences multiple phases of the intestinal calcium transport system.  Progr. Clin. Biol. Res. 168:307-12
4. Wasserman, R.H., F. Shimura, S.A. Meyer and C.S. Fullmer.  Possible roles of vitamin D-induced calcium-binding protein in intestinal calcium transport.  Prog. Biochem. 25:183-187, 1983
3. Meyer, S. A., Ewan, R. C., and Beitz, D. B. (1983) Effect of selenium on the subcellular distribution of glutathione peroxidase in rat liver, epididymal fat pad and seminal vesicle. J. Nutr. 113:394-400.
2. Wasserman, R. H., Brinkad, M. E., Meyer, S. A., and Fullmer, C. S. (1982) Evidence for multiple effects of vitamin D3 on calcium absorption: Response of rachitic chicks, with or withouth partial vitamin D3 repletion, to 1,25-dihydroxy-vitamin D3. Proc. Natl. Acad. Sci. USA 79:7939-7943.
1. Meyer, S. A., House, W. A., and Welch, R. M. (1982) Some metabolic interrelations between toxic levels of cadmium and non-toxic levels of selenium fed to rats. J. Nutr. 112:954-961.

Research Abstracts from International and National Meetings

13. Meyer, S.A., H.F. Hussin and K.A. El Sayed. Comparison of Myelostimulation by Echinacea purpurea Extracts with Analytical Fingerprints to Identify ActiveConstituents. The Toxicologist. 2014; 206(abst #789)
12. Jaligama, S., V.M. Kale, M.S. Wilbanks, E.J. Perkins and S.A. Meyer.  Bone Marrow Inflammation Precedes Delayed Myelosuppression from Hexahydro-1-Nitroso-3, 5-Dinitro-1,3, 5-Triazine (MNX) Induced in Rats.  The Toxicologist. 2013; 52(abst. #250).
11. Jaligama, S., V.M. Kale, M.S. Wilbanks, E.J. Perkins and S.A. Meyer.  Bone Marrow Inflammation Precedes Hexahydro-1-Nitroso-3, 5-Dinitro-1,3, 5-Triazine (MNX) Induced Delayed Myelosuppression in Rats.  FASEB J. 2013; 27:888.5
10. Meyer, S.A., S. Jaligama, K.A. El Sayed and T.R. Dugas. Different Toxicity Outcomes in Rats Correlated with EPR and NMR Spectra of Crude Oil from Various Sources. The Toxicologist. 2013; 122(abst. #568).
9. Jaligama, S., V.M. Kale, M.S. Wilbanks, E.J. Perkins and S.A. Meyer. Time course for hematotoxicity of MNX (hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine), RDX environmental degradation product, in rats. The Toxicologist. 2012; 126:339 (abst. #1570)
8. Meyer, S.A.,S. Jaligama and K.A. El Sayed. Crude oil from various sources yields different acute toxicity outcomes in rats: Correlation with 1H-NMR and EPR spectra. The Toxicologist. 2012; 126:35(abst. #169)
7. Jaligama, S., K.A. El Sayed, E.J. Perkins and S.A. Meyer. Hematotoxicity of environmental pollutants in rats: Munitions environmental degradate MNX and Louisiana sweet crude oil. 50th annual meeting, Society of Toxicology, Washington, DC, Mar 6-10 , 2011
6. Wilbanks, M.S., Y. Deng, B.L. Escalon, X. Guan, S.A. Meyer and E.J. Perkins. Use of toxicogenomics and network modeling to identify the Nrf2-mediated oxidative stress response pathway as a mechanism of action for nitroaromatic explosives. The Toxicologist. 2010; 114:75(abst. #348)
5. Perkins, E.J., B.L. Escalon, X. Guan and S.A. Meyer. Genomic analysis of the response and recovery of rat brain from chemically induced seizures.  EPA 2007 International Science Forum on Computational Toxicology, May 21-23, 2007, Research Triangle Park, NC
4. Meyer, S. A. (2006) Persistent anemia associated with hematotoxicity of nitro reduced degradation product MNX of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). 2006 Military Health Research Forum, San Juan, Puerto Rico, May 1-4, 2006.
3. Wetmore, B. A., and Meyer, S. A. (1999) Ethanol inhibits hepatotoxicity of herbicide alachlor. Abstracts of 9th North American ISSX Meeting. October 24-29, 1999. Nashville, TN.
2. Meyer, S. A., and Smart, R. C. (1996) Accelerated malignant conversion of mouse skin tumors co-promoted by mirex and 12-O-tetradecanoyl-phorbol-13-acetate. Proc. Am. Assoc. Cancer Res. 37:157 (Abst. # 1089)
1. Meyer, S. A., and Smart, R. C. (1995) Cell lines from a mouse squamous cell carcinoma with different mutant c-Ha-ras gene dosages characteristic of different stages of carcinogenesis. The Toxicologist 15:55 (Abst. #292)

Book Chapters

7. Meyer, S.A. and Ramasahayam, S. Echinacea IN: Encyclopedia of Toxicology, 3rd ed., Elsevier, (in press).
6. Wallace, A. D. and Meyer, S. A. Hepatotoxicity. IN:  Molecular and Biochemical Toxicology, 4th Ed. (Hodgson, E. and Smart, R., eds), John Wiley & Sons, New York, (in press)
5. Meyer, S. A.  (2001) Overview of Hepatotoxicity IN: Current Protocols in Toxicology (Maines, M.D., ed), John Wiley & Sons, New York, pp. 14.1.1-14.1.6.
4. Meyer, S. A. (2001) Overview of cellular techniques in toxicology. IN: Introduction to Biochemical Toxicology, 3rd Ed. (Hodgson, E. and Smart, R., eds), John Wiley & Sons, New York, pp. 51-65.
3. Hodgson, E., and Meyer, S. A. (1997) Pesticides IN: Comprehensive Toxicology, Vol. 9, Hepatic and Gastrointestinal Toxicology, Permagon/Elsevier, New York, pp. 369-387
2. Meyer, S. A., Chandler, J. S., and Wasserman, R. H. (1984) Vitamin D and the basolateral calcium pump of chick intestine. IN: Endocrine Control of Bone and  Calcium Metabolism, Vol. 8A (D. V. Cohn, et al., eds) Elsevier, Amsterdam, pp. 253-254.
1. Wasserman, R. H., Shimura, F., Meyer, S. A., and Fullmer, C. S. (1983) Possible roles of vitamin D-induced calcium-binding protein in intestinal calcium transport. IN: Calcium-binding Proteins 1983 (D. deBernard, et at., eds) Elsevier, Amsterdam, pp. 183-188.

Book Review
1. Meyer, S.A.  Review of Toxicology of the Human Environment:  The Critical Role of Free Radicals (Rhodes, C.J., ed.) published in Int. J. Toxicol., 20:330-1, 2001