| 24. | Hosain SB, Khiste SK, Uddin MB, Vorubindi V, Igram C, Zhang S, Hill RA, Gu X and Liu YY. 2016. Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells. Oncotarget Aug 10 [Epub ahead of print] PMID: 27517620 |
| 23. | Patwardhan GA, Hosain SB, Liu DX, Khiste SK,Zhao Y, Bielawski J, Jazwinski SM, Liu Y.Y. 2014. Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells. Biochim Biophys Acta 1841(11):1571-1580 PMID: 25195822 |
| 22. | Liu, Y.Y., Hill, R.A. and Li, Y.T. Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance. 2013. Adv Cancer Res 117:59-89 (citation>40) PMID: 23290777 |
| 21. | Gupta, V., Liu, Y.Y. 2013. New insights on glucosylceramide synthase in cancer drug resistance and myelosuppression. Biochem & Pharmacol 2:120 PMID: 25401049 |
| 20. | Hosain, S.B., Hill, R.A., and Liu, Y.Y. 2013. The role of sphingolipids in modulating pluripotency of stem cells. Trends in Stem Cell Proliferation and Cancer Research by Rodrigo Resende, Henning Ulrich, Springer, ISBN 978-94-007-6210-7, p167-191 |
| 19. | Gupta, V., Bhinge, K.N., Hosain, S.B., Xiong, K., Gu, X., Shi, R., Ambudkar, S., Jazwinski, S.M. and Liu, Y. Y. 2012. Ceramide glycosylation catalyzed by glucosylceramide synthase is a critical process maintaining the stemness of breast cancer stem cells. J Biol Chem 278(44):37195-205 (highlighted inASBMB News, citation>30) PMID: 22936806 |
| 18. | Bhinge, K., Gupta, V., Hosain, S.B., Meyer, S.A., Blaylock, B., Zhang, Q., Liu, Y.Y. 2012. The opposite effects of doxorubicin on bone marrow stem cells versus breast cancer stem cells depend on glucosylceramide synthase. Int. J. Biochem. Cell Biol. 44(11):1770-1778 PMID: 22728310 |
| 17. | Liu, Y.Y. 2011.Resuscitation of wild-type p53 tumor suppressor by disrupting ceramide glycosylation: a novel approach to target mutant p53 tumors.Cancer Res.71(20):6295-99 PMID: 21972148 |
| 16. | Liu, Y.Y., Patwardhan, G.A., Xie, P., Gu, X., Giuliano, A.E., and Cabot, M.C. 2011. Glucosylceramide synthase, a factor in modulating multidrug resistance, is overexpressed in metastatic breast carcinoma. Int. J Oncol 39:425-431 (citation>30) PMID: 21617856 |
| 15. | Liu, Y.Y., Patwardhan, G.A., Bhinge, K., Gupta, V., Gu, X., and Jazwinski, S.M., 2011. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. Cancer Res. 71(6):2276-85 (citations>40) PMID: 21278235 |
| 14. | Gupta, V., Zhang, Q. and Liu, Y.Y. 2011. Evaluation of anticancer agents using flow cytometry analysis of cancer stem cells. Methods Mol Biol. 716:179-91. PMID: 21318907 |
| 13. | Patwardhan, G.A., Liu, Y.Y. 2011. Sphingolipids and expression regulation of genes in cancer. Prog. Lipid Res. 50:104-114 (Most Read Article in 2011, citations>60) PMID: 20970453 |
| 12. | Liu, Y.Y., Gupta, V., Patwardhan, G.A., Yin, D., Bhinge, K., Zhao, Y., Bao, J., Mehendale, H., Cabot, M. C., Li, Y., and Jazwinski, S.M. 2010. Glucosylceramide Synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol Cancer 9(1):145 (highly accessed, citations>90) PMID: 20540746 |
| 11. | Patwardhan, G.A., Gupta, V., Huang, J., Gu, X., Liu, Y.Y. 2010. Direct assessment of P-glycoprotein to determine tumor response to chemotherapy. Biochem. Pharmcol. 80:72-79 (citation>20) PMID: 20298675 |
| 10. | Gupta, V., Patwardhan, G.A., Zhang, Q., Senkal, C.E., Ogretmen, B., Cabot, M.C., Jazwinski, S.M., and Liu, Y.Y. 2010. Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate the enzyme activity of glucosylceramide synthase. J. Lipid Res 51:866-874 (highlighted in ASBMB Today; citation>16). PMID: 19826105 |
| 9. | Patwardhan, G.A., Zhang, Q., Yin, D., Gupta, V., Bao, J., Senkal, C.E., Ogretmen, B., Cabot, M.C., Jazwinski, S.M., Liu, Y.Y. 2009. A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. PLoS One 4(9):e6938 (citations>40) PMID: 19742320 |
| 8. | Liu, Y.Y.,Yu, J.Y., Yin, D., Patwardhan, G., Gupta, V., Hirabayashi, Y., Holleran, W.M., Jazwinski, S.M., Giuliano, A.E., Gouaze-Andersson, V., Consoli, D.P., Cabot, M.C. 2008. A role for ceramide in driving cancer cell resistance to doxorubicin. FASEB J. 22, 2541-2551 (citations >100) PMID: 18245173 |
| 7. | Liu, Y.Y., Han, T.Y, Yu, J.Y., Bitterman, A., Le, A., Giuliano, A.E., and Cabot, M.C. 2004. Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells. J Lipid Res 45:933-940 (citations >80) PMID: 14967819 |
| 6. | Liu, Y.Y., and Cabot, M.C. 2004. Development of a mammalian Tet-on expression cell line: glucosylceramide synthase regulates TNF-a-induced apoptosis. Methods Mol. Biol. 249:177-192 PMID: 14573900 |
| 5. | Liu,Y.Y.,Han, T.Y., Giuliano, A.E. and Cabot, M.C. 2001. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J.15:719-730 (citations >280) PMID: 11259390 |
| 4. | Liu, Y.Y.,Han, T.Y., Giuliano, A.E., Hansen, N., and Cabot, M.C. 2000. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance. J. Biol. Chem. 275:7138-7143 (citation>140). PMID: 10702281 |
| 3. | Liu Y.Y.,Han, T.Y, Giuliano A.E., and Cabot, M.C. 1999. Glucosylceramide synthase potentiates cellular resistance to TNF-a induced apoptosis. Exp. Cell Res.252:464-470 (citations >80). PMID: 10527636 |
| 2. | Liu Y.Y., Rajkumar K. and Murphy L.J. 1999. Hepatic regeneration in insulin-like growth factor binding protein-1 transgenic mice. J. Hepatol. 30:674-80. PMID:10207810 |
| 1. | Liu Y.Y.,Han T.Y., Giuliano A.E. and Cabot M.C. 1999. Expression of glucosylceramide synthase converting ceramide to glucosylceramide impacts adriamycin resistance in human breast cancer cells. J. Biol. Chem. 274:1140-1146 (citation>280). PMID: 9873062 |