MALTO 2017 Program Schedule
| Sunday, May 21, 2017 | |
| Time | Event |
| 4:30-6:30 | Registration - The Clarion Hotel and Conference Center |
| 6:30-9:00 | Mixer - The Clarion Hotel and Conference Center |
| Monday, May 22, 2017 | |
| 6:45-8:00 | Continental Breakfast - The Clarion Hotel and Conference Center |
| 7:45 | Posters Setup - ULM School of Pharmacy - Bienville Room 230 |
| 8:30 | Welcoming Remarks - ULM School of Pharmacy - Bienville Room 170 |
| 8:40-10:10 O1-O4 |
Podium Session 1 - ULM School of Pharmacy - Bienville Room 170 |
| 10:10-10:40 P1-P23 |
Coffee - ULM School of Pharmacy - Bienville Room 230 (Posters available for viewing only) |
| 10:40-12:10 O5-O8 |
Podium Session 2 - ULM School of Pharmacy - Bienville Room 170 |
| 12:20-1:20 | Lunch - ULM School of Pharmacy - 1st Floor Cafeteria Posters available for viewing only - Bienville 230 |
| 1:20-2:00 O9-O10 |
Podium Session 3 - ULM School of Pharmacy - Bienville Room 170 |
| 2:05-3:05 | A. Nelson Voldeng Lecture - ULM School of Pharmacy - Bienville Room 170 |
| 3:15-5:00 P1-P24 |
Poster Session - ULM School of Pharmacy - Bienville Room 230 Student Posters: P1-P11; Postdoctoral Posters: P12-P24 |
| 7:00-9:30 | Dinner and Festivities - Bayou Landing 7805 DeSiard St. Monroe, LA |
| Tuesday, May 23, 2017 | |
| 6:45-8:00 | Continental Breakfast - The Clarion Hotel and Conference Center |
| 8:25-9:45 O11-O14 |
Podium Session 4 - ULM School of Pharmacy - Bienville Room 170 |
| 9:50-10:15 | Coffee Break - ULM School of Pharmacy - Bienville Room 230 |
| 10:20-11:20 | Industrial Career Development Forum - ULM School of Pharmacy - Bienville Room 170 |
| 11:20-12:20 | MALTO Business Meeting - ULM School of Pharmacy - Bienville Room 170 |
| 11:30-1:15 | Lunch - ULM School of Pharmacy - 1st Floor Cafeteria |
| 12:45 | MALTO Awards Ceremony and Closing Remarks ULM School of Pharmacy - Bienville Room 170 |
SUNDAY, MAY 21, 2017
4:30-6:30 Registration - The Clarion
6:00-9:00 Mixer – The Clarion
MONDAY, MAY 22, 2017
6:45-8:00 Breakfast, The Clarion
8:30 Welcoming Remarks - ULM School of Pharmacy Room 170
PODIUM SESSION 1- ULM SOP-170
Mr. Abu Bakar Siddique, Moderator
8:40 O1 INVESTIGATION OF 20S(OH)D3 AND 1,20S(OH)2D3 ANALOGS AS POTENT VDR AGONISTS AND ANTI-INFLAMMATORY AGENTS
Zongtao Lin, Srinivasa R. Marepally, Anna Y. Belorusova, Emily S. Y. Goh, Chloe Y. S. Cheng, Edith K.Y. Tang, Tae-Kang Kim, Zorica Janjetovic, John C. Bolinger, Zhongzhi Wu, Hao Chen, Duane D. Miller, Arnold E. Postlethwaite, Andrzej T. Slominski, Robert C. Tuckey, Natacha Rochel, Wei Li.
Department of Pharmaceutical Sciences, Medicine, University of Tennessee Health Science Center, Memphis, TN, Department of Integrative Structural Biology, Institute of Genetics and of Molecular and Cellular Biology, Illkirch, France. School of Chemistry and Biochemistry, University of Western Australia, Crawley, Australia, Department of Dermatology, University of Alabama at Birmingham, AL 35294, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, Department of Veterans Affairs Medical Center, Memphis TN, VA Medical Center at Birmingham, Birmingham, AL.
9:00 O2 EVALUATION OF PLECTIN AS A CANCER STEM CELL BIOMARKER
Nicole Prodan, Aaron C. Raymond, John D. Minna, D. Gomika Udugamasooriya
Department of Pharmacological & Pharmaceutical Sciences, University of Houston, Houston. Department of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX. Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, Departments of Pharmacology, and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
9:20 O3 DESIGN AND SYNTHESIS OF NOVEL CYCLIC PEPTIDES TARGETING EGFR OVEREXPRESSED CANCERS
Sitanshu S Singh, Thomas Durek, David Craik and Seetharama Jois
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe LA. The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland, Australia.
9:45 O4 DESIGN AND SYNTHESIS OF MONOAMINE OXIDASE-B INHIBITORS
Vedanjali Gogineni, Francisco León, Narayan D. Chaurasiya, Babu L. Tekwani, Manal Nael, Stephen J. Cutler, and Christopher R. McCurdy
Department of BioMolecular Sciences, Division of Medicinal Chemistry and National center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, Department of Pharmaceutical Chemistry, Tanta University, Tanta, Egypt, College of Pharmacy, University of South Carolina, Columbia, SC, Department of Medicinal Chemistry, University of Florida, Gainesville, FL.
10:10-10:40 Coffee Break - SOP-230
(POSTERS available for viewing only)
PODIUM SESSION 2- ULM SOP-110
Mr. Sitanshu Singh, Moderator
10:40 O5 STRUCTURE AND DYNAMICS OF GRAFTED PEPTIDE FOR CD2-CD58 PROTEIN-PROTEIN INTERACTION.
Pravin Parajuli, Rushikesh Sable, and Seetharama Jois
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, LA.
11:00 O6 SYNTHESIS AND EVALUATION OF DUAL-ACTING NPFF/OPIOID LIGANDS
K. McPherson, J. Lambert, M. Cunningham, J. Rimoldi, C. R. McCurdy.
Department of Biomolecular Sciences, University of Mississippi, University, MS, Department of Medicinal Chemistry, University of Florida, Gainesville, FL, UF Translational Drug Development Core, University of Florida, Gainesville, FL.
11:25 O7 THE DISCOVERY OF THIENOPYRIMIDINE DERIVATIVES ASSOCIATED WITH ANTI-H. PYROLI ACTIVITY
Alex K Mugengana, Lalit K Sharma, Lei Yang, Kevin Moran, Ekaterina Gavrish, Michael Lafleur, Richard Lee.
Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, Arietis Pharma, Boston, MA
11:50 O8 THE BK (MAXI-K) CHANNEL ANTAGONIST PENITREMS AS NOVEL LUMINAL BREAST CANCER TARGETED THERAPEUTICS
12:20-1:20 Lunch SOP Cafeteria
(POSTERS available for viewing only in SOP-230)
PODIUM SESSION 3- ULM SOP-170
Ms. Susan Egbert, Moderator
1:20 O9 OPTIMIZATION OF PYRIDO[2,3-d]PYRIMIDINONES AS DUAL ALK2/RIPK2 OR PREFERENTIAL RIPK2 INHIBITORS
Sameer Nikhar, Alexei Degterev, Gregory D. Cuny.
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX. Department of Developmental, Molecular & Chemical Biology, School of Medicine, Tufts University, Boston, MA.
1:40 O10 TARGETING BACTERIAL TOPOISOMERASE I FOR SELECTIVE ANTI-STREPTOCOCCAL DRUG DESIGN
J.A. Jones, K.E. Hevener.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, TN 38163.
2:05 30th Annual A. Nelson Volding Lecture.
The Lilly Open Innovation Drug Discovery Program: For Scientists by Scientists.
MAKING LIVES BETTER TOGETHER
Dr. Maria Alvim-Gaston, Principal Research Scientist, External Innovation and Lead Generation, Eli Lilly and Company, Lilly Corporate Center, DC 1920, Indianapolis IN.
3:00-5:00 POSTER SESSION- SOP-230 P1-P24
7:00-9:30 Dinner and Festivities:Bayou Landing 7805 DeSiard St. Monroe (click here for directions)
TUESDAY May 23, 2017
6:45-8:00 Breakfast, The Clarion
PODIUM SESSION 4- ULM SOP-170
Ms. Leeza Shrestha, Moderator
8:25 O11 DEREPLICATION OF AN ANTIFUNGAL ANTIMYCIN FROM MARINE STREPTOMYCES SPECIES
N. Vita, J. Bowling, R. Lee, A. Demonbreun, C. Jeffries, D. Fernando, M. Cheramie, R. E. Lee.
The Department of Pharmaceutical Sciences, Bioanalytical Chemistry, The University of Tennessee Health Science Center, Memphis, TN. The Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN.
8:45 O12 OLIVE OIL SECOIRIDOID OLEOCANTHAL: A NOVEL DUAL MET-HER2 INHIBITOR AND CHEMOSENSITIZER FOR THE CONTROL OF HER2-DEPENDENT BREAST MALIGNANCIES
Abu Bakar Siddique, Hassan Ebrahim, Mohamed M. Mohyeldin, Mohamed Akl, Nehad Ayoub, Amira Goda, Khalid El Sayed
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana. Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
9:05 PROOF-OF-PHARMACOLOGICAL CONCEPT OF A VITAMIN K2 BIOSYNTHESIS INHIBITOR FOR CLOSTRIDIUM DIFFICILE INFECTIONS
Shakiba Eslamimehr, Shajila Siricilla, Katsuhiko Mitachi, Ernesto Abel-Santos, Isaac Donkor, Michio Kurosu.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Av, Memphis, TN. Department of Chemistry, University of Nevada, Las Vegas, Las Vegas, Nevada.
9:25 O14 LEAD OPTIMIZATION, SYNTHESIS, IN SILICO, SAR, AND BIOLOGICAL STUDIES OF NOVEL ALLOXAZINE ANALOGUES AS POTENT AND SELECTIVE ANTITUMOR AGENTS
Brian Standard, Ahmed M. Gouda, Rabaa Al-Rousan, Doaa Samaha, Ashraf N. Abdalla, Zakaria Y. Abd Elmageed,Hamed I. Aly.
Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, Texas. Departments of Pharmaceutical Chemistry, College of Pharmacy, Umm Al-Qura University, Makkah, KSA. Department of Medicinal Chemistry, College of Pharmacy, Beni-Suef University, Beni-Suef, Egypt. Institute of Chemistry, Humboldt-Universität zu Berlin, Berlin, Germany. Department of Pharmaceutical Chemistry, College of Pharmacy, Helwan University, Cairo, Egypt..
9:50-10:15 Coffee Break ULM SOP-230
10:20-11:20 Industrial career development open forum - Dr. Gaston. B170
11:20-12:20 MALTO Business Meeting - B170
11:30-1:15 Lunch served SOP-230
12:45 MALTO Awards Ceremony & Closing Remarks - B170
POSTER SESSION- SOP-230 Monday May 22, 2017: 3:00-5:00
Student Posters: P1-P11 Postdoctoral Fellow Posters: P12-P24
P1- Mycophenolic acid derivatives as Cryptosporidium parvum IMPDH inhibitors
SeungHeon Lee, Yong Wang, Minjia Zhang, Liz Hedstrom, Gregory D. Cuny.
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX. Department of Biology and Chemistry, Brandeis University, Waltham, MA.
P2- ON THE WAY TO THE SYNTHESIS OF (-) MESEMBRINE
M.A. Albadry, S. C. Rotte, P. B. Lasonkar,A.G. Chittiboyina, I A. Khan.
Departments of BioMolecular Sciences, Division of Pharmacognosy, and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS.
P3- STABILITY AND SYNERGISTIC EFFECTS OF A PEPTIDOMIMETIC THAT TARGETS EGFR DIMERIZATION
Leeza Shrestha, Sintanshu Singh, Shanti Kanthala, Seetharama Jois.
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, LA.
P4- COMPUTER-AIDED DISCOVERY OF LICHEN METABOLITES AS NOVEL C-MET KINASE INHIBITORS FOR THE CONTROL OF TRIPLE NEGATIVE BREAST MALIGNANCIES
Susan Egbert, Abu Bakar Siddique, Heba Elsayed, Hassan Ebrahim, Mohamed Mohyeldin, Amira Goda, Joydeep Bhattacharjee, Khalid El Sayed.
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe (ULM). Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Egypt. Department of Biology, School of Sciences, ULM.
P5- GRAFTED SFTI BICYCLIC PEPTIDE FOR TARGETING ERBB2 RECEPTORS IN BREAST AND LUNG CANCER CELLS
Savannah Parker, Seetharama Jois.
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA.
P6- HARNESSING ADDITIONAL BINDING SITES TO IMPROVE THE BINDING SPECIFICITY AND ACTIVITY OF PROTEIN TARGETED LIGANDS
Samanthreddy Kedika and D. Gomika Udugamasooriya.
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX.
P7- Discovery of Potent Abelson Kinase Inhibitors from the Novel Pharmacophore
Pyrano[2,3-d]pyrimidin-7-one
Nagaraju Ashila, Zhixing Wu, Boqiao Fu, Changjiang Qiao, Mounika Chava, Dai Lu
Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, TX.
P8- Application of Hemetsberger-Knittel Reaction in the Synthesis of Indole/Azaindole-2-carboxamides for the Development of Allosteric Modulators of Cannabinoid CB1 Receptor
Sri Sujana Immadi, Teresa Olszewska, Boqiao Fu, Zhixing Wu, Dai Lu.
Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, TX.
P9- DIFFERENTIAL BINDING AND MODULATION OF MUNC13-1 ACTIVITY BY BRYOSTATIN-1 AND RESVERATROL
Youngki You, Satyabrata Pany, Francisco Blanco, Anamitra Ghosh, and Joydip Das.
Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX.
P10- ANTINOCICEPTIVE EFFECTS OF AN α9α10 NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONIST IN DIABETIC RATS: SYNTHESIS, SCREENING, AND MOLECULAR MODELING
Anqi W. Walbaum, Chunhui Zhang, E. Kim Fifer, J. Michael McIntosh, Chang-Guo Zhan, Peter A. Crooks.College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR.College of Pharmacy, University of Kentucky, Lexington, KY. Department of Psychiatry, University of Utah, Salt Lake City, UT.
P11-ISOLATION OF SECONDARY METABOLITES OF TINOSPORA CRISPA
Abidah Parveen, Zulfiqar Ali, Omer Fantoukh, Ikhlas A. Khan. Department of Biomolecular Sciences, Division of Pharmacognosy, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS.
P12- Derivatization of lipid-phosphatidylserine (PS) targeted peptide-peptoid hybrid altering non-important residues
Satya Prakash Shukla, Joseph C Manarang, D. Gomika Udugamasooriya
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX.
P13- Synthesis and Evaluation of Indole Melampomagnolide B Carbamates as Anti-Cancer Agents
Narsimha R. Penthala, Jessica Ponder, Soma Shekar Dachavaram, Craig T. Jordan, Peter A. Crooks
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, Department of Hematology, University of Colorado, Aurora, CO.
P14- On-Bead Combinatorial Synthesis of Side Arms Modified Europium (III)-DOTA Complexes
Vineeta Rustagi, Jaspal Singh, Dean Sherry, D. Gomika Udugamasooriya.
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, Advanced Imaging Research Center and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX.
P15- HOMOLOGY MODELING OF THE ACTIVE STATE CANNABINOID 1 (CB1) RECEPTOR: QUALITY ASSESSMENT, MODEL VALIDATION AND COMPARISON TO RECENTLY PUBLISHED X-RAY STRUCTURES OF THE INACTIVE STATE CB1 RECEPTOR
Pankaj Pandey, Kuldeep K. Roy, AyoOluwa Aderibigbe, Robert J. Doerksen.
Division of Medicinal Chemistry, Department of BioMolecular Sciences, Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Jadavpur, Kolkata, West Bengal, India, National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS.
P16-Synthesis and Evaluation of Novel Drug Molecules to Prevent and Treat Age-related Sarcopenia
Suresh K. Bowroju, Narsimha R. Penthala, Samuel Kakraba, Srinivas Ayyadevara, Robert J. Reis, Peter A. Crooks
Department of Pharmaceutical Sciences, College of Pharmacy, Department of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, Department of Bioinformatics, UALR/UAMS joint program, Little Rock, AR.
P17- DESIGN AND SYNTHESIS OF COMBRETASTATIN A-4 TETRAZOLE ANALOGS AS ANTICANCER AGENTS
Shobanbabu Bommagani, Narsimha R. Penthala, Monica L. Guzman, Peter A. Crooks
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, Division of Hematology & Medical Oncology, Department of Medicine Weill Cornell Medical College, New York, NY.
P18- Synthesis of Cellulose Biofilm Targeted Inhibitors via Click Chemistry Procedures
Soma Shekar Dachavaram, Peter A. Crooks*
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR
P19- Design and Synthesis of Bcl-xL Degraders as Potent Senolytic Agents
Xuan Zhang, Yingying Wang, Daohong Zhou, Guangrong Zheng.
Department of Pharmaceutical Sciences, College of Pharmaceutical, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
P20- NIR LIGHT-ACTIVATABLE PRODRUG STRATEGY TO ABALATE TUMORS THROUGH THE COMBINED EFFECTS OF PHOTODYNAMIC THERAPY AND LOCALLY RELEASED CHEMOTHERAPY.
Pallavi Rajaputra, Moses Bio, Gregory Nkepang, Pritam Thapa, Sukyung Woo, Youngjae You.
Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK. Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK.
P21- Targeted far-red light activatable prodrugs: folate receptor-targeting, optical imaging, and a combination of photodynamic therapy and site-specific chemotherapy
Gregory Nkepang, Moses Bio, Pallavi Rajaputra, Samuel Awuah, Youngjae You.
Department of Pharmaceutical Sciences, Department of Chemistry and Biochemistry, University of Oklahoma, Oklahoma City, OK
P22- Leveraging T2 Relaxation to Evaluate Allosteric Binding of Fragments to the Antibiotic Target ClpP
J. J. Bowling, E. Griffith, A. P. Singh, R. Tangallapally, R. E. Lee.
Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN. Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN.
P23- Design and synthesis of triazole derivatives of melampomagnolide B and their anti-cancer activities
Venumadhav Janganati, Jessica Ponder,Craig T. Jordan, Peter A. Crooks.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, Division of Hematology, University of Colorado, Aurora, CO, Department of Toxicology, University of Colorado, Aurora, CO.
P24- NIH COBRE NATURAL PRODUCTS NEUROSCIENCE (NPN) AT THE UNIVERSITY OF MISSISSIPPI: CHEMISTRY-DMPK CORE FACILITY
Rama S. Gadepalli and John M. Rimoldi.
Department of BioMolecular Sciences, University of Mississippi, University, MS